anigbrowl 2 days ago

Not to play down anyone's stressful life experiences, but the sort of stress they're talking about in this article is more typically correlated with stressors like violence, hunger, or institutionalization in the first decade of life.

  • onion2k a day ago

    Surely the level of stress needed to have this impact is something that needs to be studied. The researchers presumably went to an extreme to ensure a clear signal for a result, but the fact they've shown there is a significant outcome the next step is to work out how much stress is needed to cause a long term problem.

    You can't just dismiss the result because you think it's unlikely to be something that affects a lot of people.

    There is a theory in transactional analysis therapy that states adult addiction (in all its forms) pretty much always stems from childhood trauma...

    • anigbrowl a day ago

      Where did you get the idea that I was dismissing the result?

  • genxy 2 days ago

    So millions of kids in Gaza. :(

    • gejkd 11 hours ago

      All over the internet u people occupied , the same comments.

      I am neither jew nor Muslim. Can't u just leave this site alone pleaee

    • bilbo0s a day ago

      Well, to be fair, that's also hundreds of thousands of impoverished kids in in the US as well. (In fact, sometimes the kids don't even need to be impoverished for the mom to fail to feed them and beat them silly every night.)

      Also hundreds of thousands of kids throughout parts of Central and South America.

      And then of course, there are the millions throughout Africa.

      Don't even get me started on all the future Iranian soldiers we're "training" right now.

      And on and on and on.

      Point being, a world where children are not made to suffer is a world that can't exist as long as humans are humans. Because adults, from the time before time, have made victims of kids.

      I'm not sure it's able to be stopped? It seems part of the human condition.

      • estearum a day ago

        > I'm not sure it's able to be stopped? It seems part of the human condition.

        Yet somehow there are many places in which it has pretty much stopped?

      • genxy a day ago

        It wasn't an _only_, but I have long thought that if humanity loved itself. It would really try to make sure that every single child on the planet was cared for, loved and educated. That they felt safe when they went to bed and had a meal when they woke up.

        This isn't a means problem, it is a will problem.

      • squigz a day ago

        > Point being, a world where children are not made to suffer is a world that can't exist as long as humans are humans.

        > I'm not sure it's able to be stopped? It seems part of the human condition.

        The most important part of human nature/the human condition is our ability - or perhaps even need - to reflect and grow and change. It happens slowly, but it inevitably happens.

        Any way though, I'm not really sure what your point is. That we shouldn't care or try to stop it because it's "part of the human condition"? That we must care about all these injustices equally? That if we can't address all these injustices equally, we mustn't address any?

        • bilbo0s a day ago

          > Point being, a world where children are not made to suffer is a world that can't exist as long as humans are humans.

          And,

          Any way though, I'm not really sure what your point is.

          You quoted the part where I said what my point was?

          • squigz 12 hours ago

            I understand what your position is. I addressed that already.

            I don't understand what the point in taking that position in this thread is. Someone mentioned some injustice in the world. You point out many others, and suggest there might always be such injustices in the world. Why? What now? I just don't understand where the conversation is supposed to go after this, or what the person you're replying to is supposed to do with what you're saying - particularly as you haven't replied to my or the other comment's reply to your point on human nature.

            • bilbo0s 4 hours ago

              The point was that we can’t change the fact that horrible things will befall children today. You’re making the argument that human nature could change in the future. My argument is that human nature has shown no particular evidence of being able to do so since the Toba event.

              Time will tell which of us is right, but my money is on kids being victimized 10,000 years from now in many of the same ways they are today. (Adding of course whatever new and innovative methods adults come up with to harm children along the way.) Why? Because I believe human nature will not change in essence. That you believe it can doesn’t make my argument false. It means we disagree. (Though, I believe, a dispassionate analysis would find that the balance of contemporary and historical evidence is overwhelmingly on my side.)

    • philipallstar 2 days ago

      [flagged]

      • code_biologist a day ago

        https://en.wikipedia.org/wiki/Israeli_support_for_Hamas

        In a cable leaked by WikiLeaks in 2010, Amos Yadlin, former general of the Israeli Air Force, said in 2007 that Israel would be "happy" if Hamas take over Gaza and regarded it as a positive step, in order to make Gaza to be treated as a hostile state.

        The details of money flow are complicated, but there are credible rumors of Israel funding Hamas via Quatar. There's a chance Hamas would have lost leadership to the Palestinian Authority had Israel not supported it during that era.

        https://www.jpost.com/israel-hamas-war/article-799792

        Former Mossad Chief admits to government funding for Hamas via Qatar, calls policy a mistake

        • hnedeotes a day ago

          This is interesting and should make you think but it's the same issue with infiltrators/agitators in other groups. If all it takes for a group to start resorting to violence and eventually establishing as part of their identity the killing of "others", when instigated by some authority figure/small group of instigators - specially with lies and historical distortions - this itself points out that the nature of that group is problematic doesn't it?

          Specially if that group has a history with thousands of terrorist attacks across all the world, even when just counting the last 25 years. It's the same if you join a left-wing group that's "just demanding" some social justice, as an undercover paid actor, and then you steer it to start killing people who are deemed "against" their objectives, or the reason they need to act. Then some people go and said they were "infiltrated", but was it so? Or was it just waiting for some nut case to come forward?

          If I tell you to go kill all the cats in the neighbourhood and you go, you're as or more dangerous than I am for suggesting that isn't it so?

          While I'm sure Israel is no angel it doesn't seem to be the one putting criminals in hiding near schools and civilian infrastructure and I also don't understand what people want them to do? Have no country?

          So others can then do with them as they please? Like telling them to "go back to their country". While it's obviously all part of a political ploy, jews should have a right to a homeland. No-one talks about Egypt and the other surrounding countries interests in this, in having a "Palestine" identity that didn't even exist a few decades ago. In fact, if you go see the first declarations, made by some Turkish guy, looking like the brother of Abramovich, sent to Palestine at the time, there's not even mention of anything Palestine.

          And lastly, it's very rich to live in countries that have benefitted from this (oil) and follow ways of life that require this, while sipping on their $15 expresso's machiatos... So in fact, perhaps there's many called "humanists" in the west that have way more blood in their hands than they would like to understand, or pretend not to, while filling their wallets and living as good samaritans. Maybe they should globalize intifada next to their homes to see if they also like living like that.

          This is not to say that Israel should have the right to bulldoze, kill and take lands of others for building high-rise apartment complexes but as far as I know and seems to be documented, it was the supposed Palestinian Authority's that many times refused land agreements and split-state solutions... But I guess here in this website where most were covid infected it doesn't matter.

          • nashashmi a day ago

            You missed the point. Israel banks on making Gaza look like the enemy, seeks reasons to seek war, and bets on a hostile takeover of Gaza and expulsion of the people.

            At this point, Hamas’s stories are meant to feed Israel’s hunger for annihilating Gaza. No stories of dictatorship or instigation or terrorism or hostage taking or can even measure back to the violent nature of Israel. It’s not Israel “is no angel”, but Israel is this earth’s worst demon who is trying to delegitimize the Palestinians, and you are their allied propagator.

            • philipallstar 4 hours ago

              > Israel banks on making Gaza look like the enemy, seeks reasons to seek war, and bets on a hostile takeover of Gaza and expulsion of the people.

              You seem to be hanging all this on what was described as a "credible rumour". To some people the idea that Jews control the weather is a credible rumour.

            • hnedeotes 14 hours ago

              Well, it seems you're the one missing the point. Again you show your nature when you make it about "Israel is this earth's worst demon", surprised you didn't say the jews. Luckily we have records of the peaceful religion and translations of what their head figures say and think, in many places around the world, throughout history, along with their acts, and luckily not only by christians or catholics (in the sense that that shows us without a bias), and still going on today. In fact we have more than 1.000 years of history to confirm. While the left and its love for erasing history (goes back to Stalin's photoshopping pictures before there was photoshop) to make itself look good goes very well with Islam's political games. I don't think Israel has to make it look like the enemy, muslisms make it abundantly clear by themselves.

      • freegaza a day ago

        Nice, are you throwing those stones without sin from the USA pal?

    • tosti 2 days ago

      [flagged]

      • cultofmetatron 2 days ago

        > Sure, never mind the millions of jews in concentration camps. Or what about the jews being terrorized by the likes of hamas, al-queda, taliban, al-shebab, IS, or any other islamic terror organization worldwide? Over the past 80 years, the number of children involved may dwarf the figure you got from hamas.

        the levels of shamelessness here on display here is breathtaking...

        • dyzone a day ago

          It's called oppression olympics

          • flossly a day ago

            Just forgot that the Gaza oppression is ongoing, with the perpetrating govt still making claims on escalating it further, and the ww2 concentration camp oppression was stopped ~80 years ago.

            Both are bad. But thinking that there is a connection between the two is indeed olympic-level mental gymnastics.

            At least in ww2 perpetrating govt tried to hide it because they knew the ordinary citizens would not take it lightly. In the current case ordinary citizens climb hills to watch and rejoice.

          • tosti a day ago

            [flagged]

            • cultofmetatron a day ago

              hmm inquisition, conquistadores in south america, and british expansion into india, the genocide of the kumir ruge and congo under leopold and the holocaust had nothign to do with islam.

              atheist here, from my perspective, all the religions seem to lean in teh direction of violence when paired with a greedy elite.

              also have you read the old testament? large sections of it come down to "god told us to kill them so we did down to the last sheep"

              islamaphobia is a symptom of the uneducated.

      • trehalose 2 days ago

        Arguing about who's the largest group of traumatized children and which groups are less significant trivializes all childhood trauma.

      • msdz 2 days ago

        > Sure, never mind

        Where did you take the “never mind” part from their statement?

    • gejkd 11 hours ago

      [flagged]

    • nhuser2221 a day ago

      Thousands of millions they seem pretty happy now

  • thibaut_barrere 2 days ago

    I do not read this in the article, I was more understanding that half the kids of the world could be concerned to a level or another, can you quote?

  • soulofmischief 2 days ago

    Great, I had all three of those in large helpings. :)

  • blueflow a day ago

    Congrats on your safe childhood.

sajithdilshan a day ago

Whenever I’m having a dream at night, it’s always about my childhood and always at the place I grew up. It feels like my mind is a prisoner of the place I grew up. Childhood stress and trauma is deeply burnt into my brain I guess

  • cfiggers a day ago

    EMDR is an amazing thing, you might look into it. Be well, friend.

redrix 3 days ago

I remember having it drilled into me in High School that unless you did well on your finals:

1. You wouldn’t get the score you needed to get into a good University and/or accepted into the course you wanted. 2. If you didn’t get into that course, you wouldn’t be able to do <x> for a career. 3. If you DID get into the course you wanted, it needed to be at a top University (which of course required an even higher entry score) or else you’d find it hard to get a job afterwards.

Imagine all of that stress: Telling 16-18 year olds that unless you ace your tests, you won’t be able to do what you want to in life.

  • syllogism 2 days ago

    The optimal amount of stress about that stuff is not zero, and most teenagers are going to be desperately biased towards "none of this matters, just peermax".

    • AngryData a day ago

      Couldn't some of that because of how people act like EVERYTHING is the most important thing for kids to do, irregardless of how it actually stacks up, and some develop something akin to alarm fatigue and stop listening?

      Plus almost everyone can get into a college, there is only really competition for a handful of elite schools. My college wanted SAT scores for admission, I did not take the SAT, they still admitted me without question. As long as you don't fail out your first two semesters in a row most colleges don't give two craps about your highschool performance.

  • NewJazz 3 days ago

    I remember having it drilled into me in high school that I was procrastinating school work while at my mom's to avoid spending time with my dad and I was faking my sobbing for sympathy and I was a horrible person who was lucky to have a dad as good as I had and how I keep doing the same things wrong and I am a smartass prick who doesn't care about anyone but myself.

    12-14 was rough.

    School work stress was quite tame by comparison. At least your teachers don't scream at you for hours until you forget why.

    • squigz 2 days ago

      This is what I think of when I think of "early life stress" in kids - not worrying about school.

      • mrguyorama 2 days ago

        It's called "Adverse Childhood Experiences", or ACEs, and the field of psychology has found them to be extremely good predictors of future negative outcomes for a long time now.

        https://pmc.ncbi.nlm.nih.gov/articles/PMC8882933/

        Things like abuse, neglect, natural disasters, basically anything that can cause trauma or significant stress.

        Be a toddler and your mom's new boyfriend abuses both of you? Congrats, you brain has developed in a way that will not be conducive at all to your future, because instead of developing a functional reward system, you've developed a specific hyperawareness to manage the difficulty of living around one kind of abuser. This incredibly specific adaptation will of course, not prevent you from being an easy target for an entirely different type of abuser in high school.

        (It's actually not that simple of course. Multiple ACEs are predictive of future troubles, not just one, so it's more like "A child who lives in an environment of constant stress, fear, and pain is likely to have a brain that didn't develop well" with a direction of effect unstated)

        This is one reason why things like abuse and poverty are so damn cyclical. Your parents grew up in poverty and with abusive parents, so they have an elevated chance to abuse their children, and on and on and on.

        This is also one reason why something like "Free food at school for anyone who wants it" is so damn effective, because it eliminates an entire class of ACEs from all those kids, and in the US, it also eliminates the horrific humiliation machine we've built around paying for school lunch, which might not be the best way to raise kids anyway.

        • mjevans 2 days ago

          It takes a village is so true. Children are something society as a whole should invest in, and fails to do so at risk to it's own future.

          By society, I mean every one of us that plans to grow old instead of an early death.

          Wouldn't it be nice to have two or three or ideally more generations of well adjusted people that grew up not fearful of hunger, nor lack of basic shelter, medical care?

          Also, providing quality child care for any time the parent(s) are working frees up quality workers to do that... though a better work life balance would also help society.

    • exe34 a day ago

      This reminds me of my father. I used to play a game: the moment I hear something crashing or I hear him swearing, I try to guess how he was going to pin that on me. I got pretty good at that game! As an adult though, I've had several people tell me to stop apologising for existing.

  • InterviewFrog 2 days ago

    Alexander the Great won his first battle at the age of 18.

    Treating 16 to 18 year old like 5 year olds is not the right way to go about it.

    • asphodele 2 days ago

      Sitting Bull killed his first buffalo with bow and arrow from horseback at the age of 10.

    • danparsonson a day ago

      Not exactly a representative example you picked there though

    • Noaidi a day ago

      Alexander the Great died when he was 33.

  • golly_ned 3 days ago

    I don't think that's what they mean by 'early-life'.

    • astura a day ago

      ...Or 'stress' for that matter.

  • coldtea 2 days ago

    The healthy reaction for 16-18 years old is to not give a damn about that, rebel, and discover the other (or the same) sex and partying.

  • euroderf 2 days ago

    Not to mention having all this on your permanent record.

  • slfnflctd a day ago

    I was utterly convinced at age 14 that I had ruined my life and any chance of a good career. I also was pretty sure the world was going to end soon. I started smoking cigarettes and experimenting with various risky behaviors. A few years later, I became suicidal for a time.

    It wasn't until my late 20s that I started living a more 'normal' life, but by then I was a decade behind in career development and other things.

    Academic concerns may not by themselves count as trauma, but combined with other factors they can be the thing that pushes someone into total hopelessness.

  • leoh 3 days ago

    I remember having this in middle school, it was a nightmare and majorly fucked me up

  • Noaidi a day ago

    Just FYI, that type of stress is typically not included as a form of Adverse Childhood Experiences (ACE). That does not mean I think it does not matter. It does, and more so for kids with poor diets.

    My childhood ACE's: Woke up on an operating table when I was three, mother and brother attempted suicide, Mother with schizoaffective disorder, physical abuse by my brothers, psychological torture by my brother (he forced me to watch him burn a nest full of baby birds with a blow torch).

  • basisword a day ago

    Exam pressure isn't the kind of stress they're talking about.

    >> More than half of the world’s children are exposed to early-life stress from abuse, household dysfunction such as violence or drug use, or other traumatic experiences

  • porridgeraisin 2 days ago

    Is it wrong?

    • wiseowise 2 days ago

      There are many things in life that are “not wrong”, doesn’t mean you have to scar kids for life with this shit.

      • basisword a day ago

        "You need to do well in your exams because they're important for your future" is not 'scarring' kids.

  • madaxe_again a day ago

    I remember being sodomised by the geography master at primary school, and being beaten by masters almost daily. They’d withhold food and sleep from us as punishment. I wouldn’t see my parents for three months at a time. You had to exist with eyes in the back of your head.

    But shit man, yeah, exams.

Noaidi a day ago

Not a scar IMHO, but a wound that can be healed. SETD7 is a Histone Methyltransferase. Meaning it attaches methyl groups to DNA which turns genes off. But there are enzymes that remove these methyl groups as well and they are called Demethylases [1]. Many of these enzymes can be stimulated by their nutritional cofactors which are things like Zinc, Iron, and Riboflavin.

I am a product of early life trauma. Knowing these thing have helped me tremendously.

[1] https://www.uniprot.org/uniprotkb/Q8NB78/entry

  • diydsp a day ago

    Wait that's very interesting. Any suggs for bio hacking?

    Iiuc zinc can be tricky/fraught to experiment with and iron somewhat risky. Don't know about B2.

    So perhaps start with each one on small dose, one week one, two weeks off, keep a journal, making no other changes?

    And any suggs for things to avoid?

    • Noaidi a day ago

      I would never suggest anything. We each have our own genetic/environmental needs. But you can get tested for many of these nutrients to see if you have a deficiency.

  • madaxe_again a day ago

    I find enough weed to sink a battleship also works.

jdw64 3 days ago

Then my brain must be full of scars.

ls612 3 days ago

In mice.

  • leoh 3 days ago

    "In mice" is the right caveat for outcomes and the wrong one for mechanisms. Nobody’s selling you a drug here--they’re describing a chromatin change, and that’s the part rodents are actually good for.

    The alternative study design is randomizing infants to early-life stress and biopsying their hippocampi at 30. Committee’s still reviewing it.

  • dang 2 days ago

    Inmiced above.

sph 3 days ago

These pop-sci articles annoy me greatly. All I can think reading the title is “well, duh?” - they’re a complete tautology.

Let me explain: if an event or behaviour affects a person, it means that there must be a physical record of it. These types of articles confirming that such a record has been found might be great news for researchers, but for everyone else, the existence of this physical record was already known a priori. We are biological machines after all, all behaviours are encoded physically.

If there was no such scar in brain cells, there would have been no early-life stress.

This applies to other research such as “learning changes structure of the brain” or “drug addiction turns off specific neural pathways” or “brains of children with autism differ from neurotypical brains” or “athletes have more developed muscles”

  • mattmcknight 2 days ago

    Scar is also a very loaded word to use here for something that is not a scar.

  • T-A 2 days ago

    > if an event or behaviour affects a person, it means that there must be a physical record of it

    Yes, and it (or at least one of them) has now been found. Maybe you don't care about knowledge for its own sake, but as the "irritating" press release goes on to point out,

    “There are currently no treatments for what early-life stress does to the brain, partially because we have not had a clear picture of what molecular mechanisms to target,” Peña said. “This work is exciting because it reveals a clear mechanism, and also helps explain why the impact of stress is both latent and broad.

  • Byte-Naut 2 days ago

    We do all know experience has its substrate, but one thing matters more—are they encoded as stubborn neural connections, mitochondrial damage, epigenetic marks, or something else to transform it into depression, long-term inflammation, or stress susceptibility, etc.? The current evidence emphasizes epigenetics. Only if we know what the 'it' is, do we have chance to change, rather than just knowing it exists.

  • hamper653 2 days ago

    > Let me explain: if an event or behaviour affects a person, it means that there must be a physical record of it.

    That record needn’t be inside individual brain cells.

    • oharapj 2 days ago

      It also doesn’t need to be a scar.. much easier to explain things as obvious post hoc than to predict them I fear

  • neuralkoi a day ago

    This article talks about a finding related to SETD7. This has implications for new treatments.

    • Noaidi a day ago

      Yes. Any gene that is methylated can be demethylated. This is actually great news.

nemosaltat 3 days ago

When our Little, Stuart falls down we don’t even know what he remembers. [in mice]